کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1255285 971416 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Scaffold-hopping strategy toward calanolides with nitrogen-containing heterocycles
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Scaffold-hopping strategy toward calanolides with nitrogen-containing heterocycles
چکیده انگلیسی

(+)-Calanolide A was the first natural product identified as an active agent against HIV-1 and Mycobacterium tuberculosis (Mtb). In devising a scaffold-hopping strategy of structure modification of (+)-calanolide A, we focused on the synthesis of calanolides by replacing ring D with various five or six membered nitrogen-containing heterocycles, hoping to get further understanding of the structure–activity relationship.

We explored the chemistry focused on replacing ring D in (+)-calanolide A with five or six membered nitrogen-containing heterocycles which may provide a novel scaffold for anti-HIV and anti-TB agents.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 24, Issue 4, April 2013, Pages 295–298
نویسندگان
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