A new method for preparing (2Z, 4Z, 6Z)-diethyl-4,5-oxepinedicarboxylates and some 1H-azepine analogues

A new method for preparing (2Z, 4Z, 6Z)-4,5-diethyloxepinedicarboxylate by one-step is described. The synthesis of several oxepines and azepines derivatives was carried out by the reaction of substituted furans or pyrroles with diethyl acetylenedicarboxylate in boiling toluene. The effect factors for this reaction were discussed and reaction condition was optimized.