Investigation of the interaction between HIV-1 DNA and cyclic peptides by electrospray ionization mass spectrometry

The interaction between HIV-1 DNA and five cyclic peptides (CP1–CP5) was investigated using electrospray ionization mass spectrometry (ESI-MS). It revealed that CP1 [c(Ala-Tyr-Leu-Ala-Gly)] and CP4 [c(Pro-D-Tyr-Leu-D-Ala-Gly)] have the higher binding affinity with the duplex DNA among the five cyclic peptides.