کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1255553 971430 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An improved and scalable process for 3,8-diazabicyclo[3.2.1]octane analogues
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
An improved and scalable process for 3,8-diazabicyclo[3.2.1]octane analogues
چکیده انگلیسی

An improved and scalable process for substituted 3,8-diazabicyclo[3.2.1]octane was developed. N-Benzyl-2,5-dicarbethoxy-pyrrolidine 2 was reduced to N-benzyl-2,5-dihydroxymethylpyrrolidine 9 and subsequently debenzylated to afford N-Boc-2,5-dihydroxymethylpyrrolidine 10. After mesylation of the diol 10 and cyclization with benzylamine, a diversity of scaffold, 3,8-diazabicyclo[3.2.1]octane analogue 12 was obtained in a total yield of 42% in five steps.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 22, Issue 5, May 2011, Pages 523–526
نویسندگان
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