Cobalt(II) chloride accelerated one-pot three-component synthesis of α-aminophosphonates at room temperature

A simple, efficient, and general method has been developed for the one-pot, three-component synthesis of α-aminophosphonates from condensation reaction of trimethyl phosphite, aryl aldehydes and aryl amines in the presence of CoCl2·6H2O under solvent-free conditions. Thus α-aminophosphonates were synthesized relatively quickly in good yields at room temperature.