A new derivative of triterpene with anti-melanoma B16 activity from Conyza canadensis

A new derivative of triterpene named Erigeronol 1 was isolated from the EtOH extract of the aerial part of Conyza canadensis together with 15 known compounds for the first time from this plant. The structure of Erigeronol 1 was elucidated as 3-O-(hydroxy-acetyl)-23,28-dihydroxy-β-amyrin by hydrolysis and spectroscopic analysis. Erigeronol 1 showed potent cytotoxic activity with IC50 value of 7.77 ± 0.47 μg/mL against melanoma B16 determined by the 3-(4,5-dimethylthiazo-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method.