Enantioselective reduction of acetophenone analogues using carrot and celeriac enzymes system

The enantioselective reduction of acetophenone analogues catalyzed by carrot and celeriac was performed in moderate conversions and excellent enantiomeric excesses. The steric factors and electronic effects of the substituents at the aromatic ring were found to significantly affect the efficiency of the enantioselective reduction of acetophenone analogues, while they had a little effect on the enantioselectivity of acetophenone analogues reduction. It was also found that the conversions of acetophenone analogues reduction at 33 °C by means of both biocatalysts were three times as great as those at room temperature.