کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1256134 | 971456 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A spectral study of the interaction between chelerythrine chloride and cytidine
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
To study the possible anticancer mechanisms of chelerythrine (CHE), and its interactions with cytidine were investigated by UV-vis spectrophotometric and spectrofluorimetric measurements and by thermodynamic calculations. The binding of CHE to cytidine could be characterized by the hypochromic and bathochromic effects in the absorption bands, and the quenching of fluorescence intensity. The spectral data were fit by linear analysis, yielding a binding constant of 2.49 Ã 104 L molâ1at 25 °C of CHE and cytidine, and a van't Hoff enthalpy of â20.02 kJ/mol for the exothermic interaction in the standard state. In addition, with ÎrGMÎ=â25.09kJ/mol and ÎrSmÎ=17.01J/molK, the interactions should be entropy-driven.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 18, Issue 6, June 2007, Pages 722-725
Journal: Chinese Chemical Letters - Volume 18, Issue 6, June 2007, Pages 722-725
نویسندگان
Xiao Yan Zhang, Quan Ling Suo, Xiong Hui Wei,