کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1256190 | 971458 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preparation of silybin 23-esters and evaluation of their inhibitory ability against LPO and DNA protective properties
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Preparation of silybin 23-esters and evaluation of their inhibitory ability against LPO and DNA protective properties Preparation of silybin 23-esters and evaluation of their inhibitory ability against LPO and DNA protective properties](/preview/png/1256190.png)
چکیده انگلیسی
Twelve 23-esterified silybin derivatives with different patterns of substituents such as aromatic and aliphatic groups (1–12) were designed and synthesized. The antioxidative properties of these compounds were evaluated. The modified silybin analogues exhibited improved inhibitory effects against rat liver homogenate lipid peroxidation compared to silybin, with exception of the trimethoxylated ester (5) and the aliphatic one (9). Compounds 3, 5, 7, 8 and 11 displayed their protective properties on DNA cleavage in a dose-dependent manner.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 20, Issue 9, September 2009, Pages 1030–1033
Journal: Chinese Chemical Letters - Volume 20, Issue 9, September 2009, Pages 1030–1033
نویسندگان
Ke Xin Huang, Jing Xu Gong, Wei Xiong, Lei Xiang Yang, Feng Wang, Qiao Feng Tao, Yi Hang Wu, Xiao Kun Li, Joachim Stöckigt, Yu Zhao, Jia Qu,