کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1256211 | 971458 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
DNA cleavage promoted by diethylenetriaminepentaacetic acid (DTPA) derivatives
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
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چکیده انگلیسی
DTPA and its two derivatives were synthesized and used as catalysts in DNA cleavage. Under physiological conditions, a series of experiments have been done. The effects of DNA cleavage with three ligands were studied under different concentrations, cleavage time, and pH values. The results strongly suggested that the plasmid DNA (pUC 19) can be cleaved efficiently by CITC-DTPA. For the cleavage reaction catalyzed by CITC-DTPA, Form I DNA could convert to Form II mostly, and the DNA-cleavage mechanism involved an oxidative pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 20, Issue 9, September 2009, Pages 1107-1110
Journal: Chinese Chemical Letters - Volume 20, Issue 9, September 2009, Pages 1107-1110
نویسندگان
Zhong Wei Yao, Jun Xu, Da Wei Zhang, Hong Hui Lin, Chuan Qin Xia,