کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1256343 | 971468 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of novel chiral fluorinating agents, (+)- and (â)-N-fluoro-3-methyl-3-(4-methylphenyl)-2H-benzo[e][1,2]thiazine-1,1,4-triones
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of novel chiral fluorinating agents, (+)- and (â)-N-fluoro-3-methyl-3-(4-methylphenyl)-2H-benzo[e][1,2]thiazine-1,1,4-triones Synthesis of novel chiral fluorinating agents, (+)- and (â)-N-fluoro-3-methyl-3-(4-methylphenyl)-2H-benzo[e][1,2]thiazine-1,1,4-triones](/preview/png/1256343.png)
چکیده انگلیسی
Treatment of N-t-butylbenzenesulfonamide with an excess of BuLi, followed by the reaction with methyl 2-(4-methylphenyl)propanoate, gave the corresponding 2-carboxybenzenesulfonamide, which underwent a sequence of consecutive N-deprotective cyclization process mediated by TMSCl-NaI-MeCN reagent to afford the N-sulfonylimine. Following the bromination and ring expansion, 3-methyl-3-(4-methylphenyl)-2H-benzo[e][1,2]thiazine-1,1,4-trione was obtained. Optical resolution of the racemic benzosultam using (â)-menthoxyacetyl chloride, furnished the optically pure (+)- and (â)-3-methyl-3-(4-methylphenyl)-2H-benzo[e][1,2]thiazine-1,1,4-triones, which were fluorinated with FClO3 to produce the corresponding chiral N-F agents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 19, Issue 8, August 2008, Pages 907-910
Journal: Chinese Chemical Letters - Volume 19, Issue 8, August 2008, Pages 907-910
نویسندگان
Hui Min Sun, Zhao Peng Liu, Long Qian Tang,