کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1256356 | 971468 | 2008 | 4 صفحه PDF | دانلود رایگان |

The inclusion interaction between three types of methylated-β-cyclodextrins (Me-β-CDs) and albendazole (ABZ) was studied by spectrofluorimetry. The result showed that Me-β-CDs reacted with ABZ to form an inclusion complex, 1:1 stoichiometry for Me-β-CDs−ABZ complex was established and its association constant have been determined from fluorescence data by Benesi-Hildebrand's method (double reciprocal plots). It was noted that 2,6-DM-β-CD exhibited stronger binding ability than other Me-β-CDs. Based on the significant enhancement of fluorescence intensity of inclusion complex, a simple and highly sensitive fluorimetric method is proposed for the determination of ABZ in the presence of 2,6-DM-β-CD. The proposed method was successfully applied to the determination of ABZ in tablets and human urine.
Journal: Chinese Chemical Letters - Volume 19, Issue 8, August 2008, Pages 951–954