کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1256536 | 971488 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and anticancer activities of porphyrin induced anticancer drugs
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and anticancer activities of porphyrin induced anticancer drugs Synthesis and anticancer activities of porphyrin induced anticancer drugs](/preview/png/1256536.png)
چکیده انگلیسی
In view of the property of porphyrin's accumulation selectively in tumor, the ftorafur was modified by binding a porphyrin block to improve its tumor targeting and reduce its side effects. These novel porphyrin derivatives and metal compounds were synthesized under mild conditions with satisfactory yield, and the constructions of all these new compounds were characterized by UV, IR, MS, 1H NMR spectra and elementary analysis. Their anticancer activities were evaluated by MTT assay; the results indicated that the anticancer activities of compounds 4a-c were twice as high as that of ftorafur.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 18, Issue 11, November 2007, Pages 1331–1334
Journal: Chinese Chemical Letters - Volume 18, Issue 11, November 2007, Pages 1331–1334
نویسندگان
Dong Hong Li, Jun Lin Diao, Ke Gui Yu, Cheng He Zhou,