A facile approach to prepare hybrid nanoparticles with morphology controlled by the thickness of glyco-shell

Herein, we designed a novel amphiphilic triblock glycopolymer poly(oligo(ethyleneglycol) methacrylate)-block-poly(maltopyranoside methacrylate)-block-polystyrene (POMA-b-PMal-b-PS) via the combination of reversible addition-fragmentation chain transfer (RAFT) polymerization and post-polymerization modification. The micelles with core–shell–corona structures were prepared by direct self-assembly of this glycopolymer in water. We found that these micelles can be used in in situ formation and stabilization of AuNPs. By controlling the thickness of glyco-shell, we successfully obtained Janus particles and raspberry-like particles with AuNPs in the sugar shell.

We successfully obtained Janus and raspberry-like hybrid particles, by using micelles formed by triblock glycopolymer poly(oligo(ethyleneglycol) methacrylate)-block-poly(maltose methacrylate)-block-polystyrene (POMA-b-PMal-b-PS), within which AuNPs were in glyco-shell. The thickness of glyco-shell determined the Janus or rasberry-like morphology.Figure optionsDownload as PowerPoint slide