کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1256776 971529 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A light-regulated synthetic ion channel constructed by an azobenzene modified hydraphile
ترجمه فارسی عنوان
یک کانال یونی مصنوعی تنظیم شده توسط یک هیدرافیلد اصلاح شده با آزوبنزن ساخته شده است
کلمات کلیدی
کانال یون مصنوعی، حمل و نقل یون های سبک کنترل شده، هادی گرافیک، عکسزومیزاسیون آزبنزن، خودآموزی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
چکیده انگلیسی

Biological ion channels are key molecules for cellular regulation and communication. To mimic the structure and functions of nature ion channels, a new class of light-regulated transmembrane ion channels was reported based on tri(macrocycle) hydraphile and azobenzene photoswitch (hydraphile 1). The liposome-based proton transport assays showed that hydraphile 1 exhibited excellent transmembrane activity (Y), and Ymax arrived 0.7 at 40 μmol/L. The successful isomerization of azobenzene moiety was confirmed and qualified by UV and NMR spectra. Upon alternative irradiation of 365 nm UV light and 450 nm visible light, the transmembrane activity of hydraphile 1 was regulated between 0.35 and 0.5, reversibly. All the obtained results have demonstrated the promise of developing excellent synthetic ion channels with ion gating properties based on simple molecular design.

A light-regulated synthetic ion channel with hydraphile as the channel architecture and azobenzene as the regulation unit was reported. Photoisomerization changes the transmembrane length of the channel, thus results in regulated ion transport.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 26, Issue 7, July 2015, Pages 851–856
نویسندگان
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