Two homosecoiridoids from the flower buds of Lonicera japonica

Two new homosecoiridoids, named loniaceticiridoside (1) and lonimalondialiridoside (2), were isolated from an aqueous extract of the flower buds of Lonicera japonica. Their structures including the absolute configuration were determined by extensive spectroscopic studies, especially by 2D NMR and CD data analysis. A proposed biosynthetic pathway and preliminary investigations of the biological activity of compounds 1 and 2 are also discussed.

Two new homosecoiridoids, named loniaceticiridoside (1) and lonimalondialiridoside (2), were isolated and characterized from an aqueous extract of the flower buds of Lonicera japonica. The compounds exhibited anti-inflammatory activity against the release of glucuronidase in rat polymorphonuclear leukocytes induced by the platelet-activating factor.Figure optionsDownload as PowerPoint slide