Alumina-supported heteropoly acid: An efficient catalyst for the synthesis of azaarene substituted 3-hydroxy-2-oxindole derivatives via C(sp3)H bond functionalization

A method of C(sp3)H bond functionalization of methyl azaarenes catalyzed by alumina-supported heteropoly acid and addition to isatins was developed. This transformation could be used for the synthesis of biologically important 3-hydroxy-2-oxindole derivatives in good to excellent yields and the catalyst could be reused for six times without significant decrease in activity.

C(sp3)H bond functionalization of methyl azaarenes catalyzed by alumina-supported heteropoly acid and nucleophilic addition to isatins was developed. This transformation could be used for the synthesis of bioactive 3-hydroxy-2-oxindole derivatives in good to excellent yields and the catalyst could be reused for six times without significant decrease in activity.Figure optionsDownload as PowerPoint slide