Synthesis and fungicidal activity study of novel daphneolone analogs with 2,6-dimethylmorpholine

The title compounds, 2,6-dimethylmorpholine-containing daphneolone analogs, were designed and synthesized on the basis of natural product 1,5-diphenyl-2-penten-1-one (I) from Stellera chamaejasme L. Preliminary bioassay showed that these compounds exhibited moderate to good fungicidal activities. Between the two isomers of target compounds, the fungicidal activities of the isomer with cis-2,6-dimethylmorpholine were better than the isomer with trans-2,6-dimethylmorpholine moiety.