Synthesis of nucleoside tetraphosphates and dinucleoside pentaphosphates from nucleoside phosphoropiperidates via the activation of P(V)N bond

A novel and efficient method for the preparation of nucleoside 5′-tetraphosphates has been developed by coupling nucleoside 5′-phosphoropiperidates with triphosphate reagent in the presence of 4,5-dicyanoimidazole (DCI) activator. Further coupling of the nucleoside 5′-tetraphosphates with nucleoside 5′-phosphoropiperidates via the P(V)N activation strategy provided a reliable synthetic method for both symmetrical and asymmetrical dinucleoside pentaphosphates.

The P(V)N activation methods for the synthesis of nucleoside tetraphosphates and dinucleoside pentaphosphates have been developed.Figure optionsDownload as PowerPoint slide