کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1256981 | 971539 | 2015 | 5 صفحه PDF | دانلود رایگان |
Chemical modification of penicillin β-lactam ring was made. Six thiazolidine amides were produced through N4-C7 β-lactam ring opening of penicillin V methyl ester with various aliphatic, aromatic, and heterocyclic primary amines. Five 8-hydroxypenillic acid derivatives with side chains of methyl, propyl, benzyl, and diethylaminoethyl groups were yielded via β-lactam ring rearrangement from 6-aminopenicillanic acid (6-APA). Parallel synthetic methods were used for the alkylation of 8-hydroxypenillic acid and β-lactam ring opening of penicillin V methyl ester. The biological activities of the compounds were evaluated.
Chemical modification of penicillin β-lactam ring was made. Six thiazolidine amides were produced through N4-C7β-lactam ring opening of penicillin V methyl ester with various aliphatic, aromatic, and heterocyclic primary amines. Five 8-hydroxypenillic acid derivatives with side chains of methyl, propyl, benzyl, and diethylaminoethyl groups were yielded via β-lactam ring rearrangement from 6-aminopenicillanic acid (6-APA).Figure optionsDownload as PowerPoint slide
Journal: Chinese Chemical Letters - Volume 26, Issue 1, January 2015, Pages 113–117