کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1256991 | 971539 | 2015 | 5 صفحه PDF | دانلود رایگان |
An efficient and high-yielding synthesis of N2-arylaminopyrimidine-5-carbonitrile derivatives starting from arylamines and 2-methylthio-pyrimidine-5-carbonitrile derivatives has been developed in the presence of cesium carbonate as basic reagent. This new protocol showed high chemical tolerance for a range of functional groups, and only the methylthio substituent on C2 of the pyrimidine ring was replaced with arylamine derivatives under the reaction conditions.
An efficient, high-yielding and transition metal-free synthetic method for the preparation of C2-functionalized pyrimidine derivatives was developed via the direct nucleophilic substitution reaction of 2-methylthio-pyrimidine derivatives with arylamines as mild nucleophiles.Figure optionsDownload as PowerPoint slide
Journal: Chinese Chemical Letters - Volume 26, Issue 1, January 2015, Pages 152–156