کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1257321 | 971556 | 2015 | 5 صفحه PDF | دانلود رایگان |
An efficient method has been developed for the synthesis of a series of (20R)-panaxadiol derivatives (4a–w) using a continuous-flow microreactor. The antitumor activities of the newly synthesized compounds were evaluated in vitro in two human prostate adenocarcinoma tumor cell lines (i.e., PC-3 and LNCaP cells), and their cytotoxicities were evaluated using a standard MTT assay. Compounds 4c, 4h, 4p, 4q and 4s exhibited higher antitumor activities toward PC-3 cell line than panaxadiol, which was used as a reference standard.
A series of panaxadiol derivatives (4a-w) were synthesized using a continuous-flow microreactor. The antitumor activity was evaluated in vitro in two human prostate adenocarcinoma tumor cell lines, and their cytotoxicities were evaluated using a standard MTT assay.Figure optionsDownload as PowerPoint slide
Journal: Chinese Chemical Letters - Volume 26, Issue 3, March 2015, Pages 334–338