کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1257326 971556 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Concise synthesis of dopexamine dihydrochloride via benzyl protecting protocol
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Concise synthesis of dopexamine dihydrochloride via benzyl protecting protocol
چکیده انگلیسی

Benzyl protecting protocol was first employed in two routes for the concise synthesis of dopexamine dihydrochloride. This protecting group could be cleanly removed under mild condition and no unacceptable ion was brought to the final product. The total yield of route I was 43.8% from phenylacetic acid, while it was 54.1% of route II from 2-(3,4-bis(benzyloxy)phenyl)acetic acid. The titration purity of the final product was more than 99.5%, while any single or total impurities met the known standard of the drug by HPLC analysis. The measured residual palladium met an acceptable limit (<1 ppm) as an API for injection.

Benzyl protecting protocol was first employed for the concise synthesis of dopexamine dihydrochloride. The protecting group could be cleanly removed under mild condition and no unacceptable ion was brought to the final product.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 26, Issue 3, March 2015, Pages 357–360
نویسندگان
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