کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1257327 | 971556 | 2015 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Highly chemoselective lipase from Candida sp. 99-125 catalyzed ring-opening polymerization for direct synthesis of thiol-terminated poly(ɛ-caprolactone) Highly chemoselective lipase from Candida sp. 99-125 catalyzed ring-opening polymerization for direct synthesis of thiol-terminated poly(ɛ-caprolactone)](/preview/png/1257327.png)
Lipase from Candida sp. 99-125 catalyzed ring-opening polymerization of ɛ-caprolactone in the presence of 6-mercapto-1-hexanol was presented as a new metal-free approach for direct synthesis of well-defined thiol-terminated poly(ɛ-caprolactone). Remarkably, high chemoselectivity of lipase from Candida sp. 99-125 toward hydroxyl and thiol was exhibited and quantitative thiol fidelity over 90% was achieved. The tedious protecting/deprotecting steps for thiol and metal residue were avoided. The polymerizations with around 70% monomer conversion were conducted in bulk and toluene at relative low temperature of 40 °C. Number–average molecular weight of resulted polymers ranged from 3000 to 4700 Da by changing the feed ratio between monomer and initiator. The structures of obtained thiol-terminated poly(ɛ-caprolactone) were demonstrated by combining NMR and SEC analyses.
High chemoselectivity of lipase from Candida sp. 99-125 toward hydroxyl and thiol was exhibited. Well-defined thiol-terminated poly(ɛ-caprolactone) with over 90% thiol fidelity was directly obtained under mild conditions.Figure optionsDownload as PowerPoint slide
Journal: Chinese Chemical Letters - Volume 26, Issue 3, March 2015, Pages 361–364