A simple and efficient procedure for the synthesis of optically active s-triazolothiadiazole derivatives

A series of novel s-triazolothiadiazoles 3a–h were prepared by condensation reaction of substituted amino triazoles 1a–b with N-phethaloyl-l-amino acids 2a–d in the presence of the phosphoroxy chloride (POCl3) as an anhydrous reagent. The structure of all synthesized compounds was confirmed by IR, 1H NMR, and 13C NMR spectroscopy.