Metal-free synthesis of substituted phenols from arylboronic acids in water at room temperature

A convenient, efficient and practical metal-free method for the synthesis of substituted phenols from arylboronic acids has been developed. The protocol uses hydrogen peroxide as a hydroxylating agent, ammonium bicarbonate as an additive, and the reactions were conveniently performed in water at room temperature. The method shows an excellent tolerance of functional groups, so it will find a wide variety of applications in academic and industrial research.

A convenient, efficient and practical metal-free method for the synthesis of substituted phenols from arylboronic acids has been developed. The protocol uses hydrogen peroxide as a hydroxylating agent, ammonium bicarbonate as an additive, and the reactions were conveniently performed in water at room temperature.Figure optionsDownload as PowerPoint slide