کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1257416 971561 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Improved and efficient synthesis of Maxacalcitol
ترجمه فارسی عنوان
سنتز بهبود یافته و کارآمد ماکسالسیتول
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
چکیده انگلیسی

Maxacalcitol, the 22-oxa-derivative of 1α, 25-dihydroxyvitamin D3, has been used as an antihyperparathyroidism and antipsoriatic drug. In this paper, an alternative synthetic route has been developed using commercially available vitamin D2 as the starting material. In addition, as a key intermediate, the asymmetric synthesis of 20(S)-alcohol 14 with the chiral auxiliary (R-CBS) was described for the first time. This new synthetic route afforded Maxacalcitol with improved overall yield (13.9%) in eleven steps.

In this paper, an alternative synthetic route has been developed using commercially available vitamin D2 as the starting material for the synthesis of Maxacalcitol. In addition, as a key intermediate, the asymmetric synthesis of 20(S)-alcohol 14 with the chiral auxiliary (R-CBS) was described for the first time.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 25, Issue 5, May 2014, Pages 771–774
نویسندگان
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