Bioactive compounds from Selaginella involven Spring that protect PC-12 cells

Two new compounds named as 3β,12,16-trihydroxy-6,8,11,13-abietatrien (1), (8R,8′S)-4,4′,8-trihydroxyl-3,3′-dimethoxyl-9′-lignanolide (2) and a new natural product 4,4′-dihydroxyl-3,3′,5,5′-dimethoxyldiphenyl diketone (3) were isolated from the whole herbs of Selaginella involven Spring. The structures were elucidated by spectroscopic analyses including UV, IR, 1D, 2D NMR and MS methods. Additionally, these three compounds exhibited potent protective effect against the injury of PC-12 cells induced by hypoxia/reoxygenation.

Two new compounds named as 3β,12,16-trihydroxy-6,8,11,13-abietatrien (1), (8R,8′S)-4,4′,8-trihydroxyl-3,3′-dimethoxyl-9′-lignanolide (2) together with a new natural product 4,4′-dihydroxyl-3,3′,5,5′-dimethoxyldiphenyl diketone (3) were isolated from the whole herbs of Selaginella involven Spring. They all exhibited potent protective effect against the injury of PC-12 cells induced by hypoxia/reoxygenation.Figure optionsDownload as PowerPoint slide