کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1257562 971569 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and in vitro antimicrobial activity of N-arylquinoline derivatives bearing 2-morpholinoquinoline moiety
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Synthesis and in vitro antimicrobial activity of N-arylquinoline derivatives bearing 2-morpholinoquinoline moiety
چکیده انگلیسی

A new series of N-arylquinoline derivatives 5a-x bearing 2-morpholinoquinoline moiety has been synthesized by one pot base catalyzed cyclocondensation reaction of 2-morpholinoquinoline-3-carbaldehydes 2a-c, malononitrile 3 and β-enaminones 4a-h. All the synthesized compounds were screened for their in vitro antimicrobial activity against six bacterial pathogens, namely Streptococcus pneumoniae, Clostridium tetani, Bacillus subtilis, Salmonella typhi, Vibrio cholerae, Escherichia coli and against two fungal pathogens, Aspergillus fumigatus and Candida albicans using broth microdilution MIC method. Of the compounds studied, majority of the compounds were found to active against C. tetani, B. subtilis and C. albicans as compared to first-line standard drugs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 23, Issue 4, April 2012, Pages 427–430
نویسندگان
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