Copper and amine free Sonogashira cross-coupling reaction catalyzed by efficient diphosphane–palladium catalyst

The commercially available diphosphane ligand MeO-BIPHEP was first investigated in the palladium-catalyzed Sonogashira reaction in the absence of copper and amine. The coupling of various aryl bromides and aryl chlorides with phenylacetylene gave moderate to excellent yields.