The applications of Schiff bases in Ti-catalyzed asymmetric alkynylation of aldehydes

Sciff bases 1 and 2, which were derived from chiral aminoalcohols, were used as ligands in Ti-catalyzed asymmetric alkynylation of aldehydes. Good enantioselectivities (up to 88% ee) and high chemical yields (80–90%) were obtained.