کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1258865 1496517 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and biological evaluation of novel s-triazine based aryl/heteroaryl entities: Design, rationale and comparative study
ترجمه فارسی عنوان
سنتز و ارزیابی بیولوژیکی موجودات آیریل / هتروآریل مبتنی بر سنتز تریازین: طراحی، منطق و مطالعه مقایسه ای
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
چکیده انگلیسی

The urgent need in search of new biological entities to fight back with recent drug-resistant microbial flora, has led us report a library of s-triazine derivatives. The intermediate 4-((4-chloro-6-methoxy-1,3,5-triazin-2-yl)amino)benzonitrile 3 was substituted with various thiophenol, phenol, aniline and piperazine/piperidine/morpholine moieties to furnish the final 35 target compounds i.e. (4a–j), (5a–j), (6a–g) and (7a–h), respectively. These compounds were screened for in vitro antibacterial evaluation against bacteria (Staphylococcus aureus MTCC 96, Bacillus cereus MTCC 619, Escherichia coli MTCC 739, and Pseudomonas aeruginosa MTCC 741) and antifungal activity against fungi (Candida albicans MTCC 183, Aspergillus niger MTCC 282, and Aspergillus clavatus MTCC 1323). The title compounds were further subjected for antituberculosis activity against Mycobacterium tuberculosisH37Rv strain using the BACTEC MGIT method. In this biological evaluation, thiophenol derivatives were found to be more active than the rest (i.e. -Thiophenol > -piperazine > -Aniline > -phenol). The final compounds were characterized by FT-IR, 1H NMR, 13C NMR, mass spectroscopy and elemental analysis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Association of Arab Universities for Basic and Applied Sciences - Volume 20, June 2016, Pages 8–18
نویسندگان
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