Eco-efficient ultrasonic responsive synthesis of pyrimidines/pyridines

• We report a simple, eco-friendly and cost-effective method for synthesis of pyrimidine/pyridine derivatives.
• Efficient protocol using ultrasound irradiation-with short reaction times at moderate conditions.
• One-pot synthesis with excellent yields.

Using ultrasound irradiation, two simple one-pot multicomponent methods are described for syntheses of highly functionalized pyrimidine/pyridine derivatives in excellent yields in the presence of NaOH at room temperature. While one route involved aromatic aldehyde, thiourea and acetoacetanilide, the other employed aromatic aldehyde, malononitrile and benzyl mercaptane or EtOH. These approaches afford several advantages over former and contemporary reaction methodologies in terms of operational simplicity, simple work-up procedure, higher yield, short reaction time and environment friendly protocols.