Ultrasound mediation for efficient synthesis of monoarylidene derivatives of homo- and heterocyclic ketones

Ultrasonic irradiation was efficiently used for high yield synthesis of monoarylidene derivatives of cyclic systems directly from the reaction of ketone with various aldehydes under solvent-free conditions. Reactions took place rapidly in the presence of catalytic amounts of pyrrolidine, while no significant formation of the undesired bis by-products was observed. Moreover, the procedure was applicable to both homo- and heterocyclic ketones.

► Ultrasonic irradiation causes efficient synthesis of monoarylidenes of ketones.
► Various products are directly obtained under solvent-free conditions.
► Catalytic amounts of the organocatalyst are enough for the reaction to proceed.
► No significant formation of the undesired bis by-products is observed.
► The procedure is applicable to both homo- and heterocyclic ketones.