کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1265466 | 972222 | 2012 | 11 صفحه PDF | دانلود رایگان |

The wide use of high intensity ultrasound (HIU) in modern medicine raises the question of bio-safety. It has been shown that the effect of HIU in biological media may have similarity to the effects of ionizing radiation. Exposure of biological media to HIU field may lead to cavitation phenomenon followed by formation of free radicals such as hydroxyl radical (OH) and the super-oxide ion (O2–). These are highly reactive species that may cause harmful effects and induce oxidative stress. In the present study we employed electron spin resonance (ESR) spectroscopy together with spin traps to quantify the dynamics of hydroxyl radical formation during exposure to HIU field in the presence of different amounts of six antioxidants. Thus, the efficiency of water-soluble antioxidants, namely Allicin, Melatonin, Deoxyribose, Trolox, Nuphlutine and Hermidin, to suppress accumulation of OH radicals was examined. The results show that among the six, Trolox and Allicin reduce hydroxyl concentration with the highest efficiency.
► In the present study we employed electron spin resonance (ESR) spectroscopy together with spin traps to quantify the dynamics of hydroxyl radical formation during exposure to high intensity ultrasound field in the presence of different amounts of six water soluble antioxidants: Allicin, Melatonin, Deoxyribose, Trolox, Nuphlutine and Hermidin.
► The results show that among the six antioxidants examined, Trolox and Allicin reduce hydroxyl radicals with the highest efficiency.
► The experimental data is discussed and rationalized using data obtained by electronic structure calculations on these systems.
Journal: Ultrasonics Sonochemistry - Volume 19, Issue 2, March 2012, Pages 314–324