کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1268462 972406 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Optimizing clinical performance and geometrical robustness of a new electrode device for intracranial tumor electroporation
موضوعات مرتبط
مهندسی و علوم پایه شیمی الکتروشیمی
پیش نمایش صفحه اول مقاله
Optimizing clinical performance and geometrical robustness of a new electrode device for intracranial tumor electroporation
چکیده انگلیسی

Current technology has limited applicability for electroporation based treatment of deep-seated tumors, and is in general, not optimized in terms of compliance with clinically relevant parameters. Here we present a novel electrode device developed for electrotransfer of antineoplastic drugs and genes to intracranial tumors in humans, and demonstrate a method to optimize the design (i.e. geometry) of the electrode device prototype to improve both clinical performance and geometrical tolerance (robustness). We have employed a semiempirical objective function based on constraints similar to those used in radiation oncology. The results show that small geometrical changes may yield a significant improvement. For example, a 2 mm displacement of 6 electrodes yields 14% better compliance with the clinical parameters, compared to the prototype, and additionally makes the electrode device less sensitive to random geometrical deviations. The method is readily applicable to other electrode configurations.

Graphical AbstractFigure optionsDownload as PowerPoint slideResearch Highlights
► Novel electrode device for intracranial electroporation introduced.
► Volume definitions from radiation therapy employed in electroporation based treatment.
► Improved clinical performance of electrode device by semiempirical optimization.
► Geometrical robustness of electrode device assessed and improved.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioelectrochemistry - Volume 81, Issue 1, April 2011, Pages 10–16
نویسندگان
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