Development of a strontium-containing hydroxyapatite bone cement

A new route was developed to synthesis a new type of strontium-containing hydroxyapatite (Sr-HAP) bone cement with precursors of tetracalcium phosphate (TTCP), strontium hydrogen phosphate (DSPA), dicalcium phosphate (DCPA), phosphate acid and water. The processing parameters and fundamental properties including pH value, setting time, compressive strength of final hardened body and the cytotoxicity for serial extracts of each cements were investigated. The result shows that the final product of the cement after setting for 24 h is nonstoichiometic Sr-containing hydroxyapatite (Ca10−m−xSrx□m(HPO4)y(PO4)6−y(OH)2−2m□2m, 0