کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1268923 972428 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Voltammetric determination of terbinafine in biological fluid at glassy carbon electrode modified by cysteic acid/carbon nanotubes composite film
موضوعات مرتبط
مهندسی و علوم پایه شیمی الکتروشیمی
پیش نمایش صفحه اول مقاله
Voltammetric determination of terbinafine in biological fluid at glassy carbon electrode modified by cysteic acid/carbon nanotubes composite film
چکیده انگلیسی

The electrochemical oxidation of L–cysteine (CySH) in presence of carbon nanotubes (CNTs) formed a composite film at a glassy carbon electrode (GCE) as a novel modifier for directly electroanalytical determination of terbinafine without sample pretreatment in biological fluid. The determination of terbinafine at the modified electrode with strongly accumulation was studied by differential pulse voltammetry (DPV). The peak current obtained at + 1.156 V (vs. SCE) from DPV was linearly dependent on the terbinafine concentration in the range of 8.0 × 10− 8–5.0 × 10− 5 M in a B–R buffer solution (0.04 M, pH 1.81) with a correlation coefficient of 0.998. The detection limit (S/N = 3) was 2.5 × 10− 8 M. The low-cost modified electrode showed good sensitivity, selectivity, and stability. This developed method had been applied to the direct determination of terbinafine in human serum samples with satisfactory results. It is hopeful that the modified electrode will be applied for the medically clinical test and the pharmacokinetics in future.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioelectrochemistry - Volume 72, Issue 1, February 2008, Pages 107–115
نویسندگان
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