A one-pot three-component synthesis of 4,6-diarylpyrimidin-2(1H)-ones (DAPMs) using atomized sodium in THF under sonic condition

• This one-pot route is mild and inexpensive.
• Reaction goes to completion in very short time with high yields.
• The use of small amount (2.0 mg atom) of catalyst.
• The catalyst is cheap, easy to handle and commercially available.
• The reactions are energy efficient and involve use of a green technique.

A simple and an efficient procedure for the synthesis of 4,6-diarylpyrimidin-2(1H)-ones using atomized sodium/THF via a one-pot three-component Biginelli-like cyclocondensation of an aldehyde, a methyl ketone and urea under ultrasonic condition is developed. The method is mild and inexpensive; yields are high and the reactions go to completion within 10–15 min.