کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1269048 972438 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The electron transfer reactivity of kaempferol and its interaction with amino acid residues
موضوعات مرتبط
مهندسی و علوم پایه شیمی الکتروشیمی
پیش نمایش صفحه اول مقاله
The electron transfer reactivity of kaempferol and its interaction with amino acid residues
چکیده انگلیسی

In this work, the electron transfer reactivity of kaempferol was studied and the interaction in vivo between kaempferol and protein was simulated. Dimethylsulfoxide (DMSO) as an aprotic solvent was employed to simulate the specific environment. Various residues of amino acids were used to study the effect of the amino acids in the active site of protein on the electron transfer reactivity of kaempferol. Experimental results revealed that the redox activity of kaempferol was different in aprotic medium DMSO from that in water, and a new redox process was further found. Of all the residues tested, nitrogenous nucleophile, for example, imidazole, was observed to be able to facilitate the electron transfer of kaempferol, and the mechanism was also proposed. This work might provide a simple model to study the electron transfer reactivity of some small active organic molecules, especially medicines, in specific environment, which might approach a more accurate understanding of the activity of some medicines in vivo.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioelectrochemistry - Volume 72, Issue 2, April 2008, Pages 169–173
نویسندگان
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