Silica chloride catalyzed efficient route to novel 1-amidoalkyl-2-naphthylamines under sonic condition in water

A one-pot three-component condensation of an aldehyde, 2-naphthylamine, and acetamide has been achieved by sonication at 35 kHz. The reaction is catalysed by silica chloride in aqueous medium. This protocol afforded corresponding 1-amidoalkyl-2-naphthylamines in shorter reaction durations, and in high yields. The method involves simple work-up procedure, and avoids use of hazardous reagents.

► Development of new energy efficient synthetic methodology for γ-aminoamides.
► An efficient use of silica chloride as heterogeneous catalysts.
► Use of universal solvent–water as a reaction medium.
► One-pot multi-component synthesis of novel amidoalkyl-2-naphthylamines.
► Use of alternate source of energy-ultrasound in the synthesis of substituted amides.