Glycine catalyzed convenient synthesis of 2-amino-4H-chromenes in aqueous medium under sonic condition

A one-pot three-component condensation of an aldehyde, malononitrile, and resorcinol has been achieved by ultrasound method. The reaction has been catalyzed by glycine in aqueous medium. This protocol afforded corresponding 2-amino-4H-chromenes in shorter reaction times, high yields and simple work-up procedures with the green aspects by avoiding toxic reagents.

► Development of new synthetic methodology.
► An efficient use of glycine as an organocatalysts.
► Universal solvent as a reaction medium.
► One-pot multi-component synthesis of 2-amino-4H-chromenes.
► Use of alternate source of energy-ultrasound in synthesis of chromenes.