کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
1271027 1496914 2014 9 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
Information processing through a bio-based redox capacitor: Signatures for redox-cycling
ترجمه فارسی عنوان
پردازش اطلاعات از طریق یک خازن ردوکس مبتنی بر زیستی: امضا برای بازسازی دوچرخه سواری
کلمات کلیدی
تولید زباله، کیتوزان، الکترود رکسکس دوچرخه سواری، پردازش سیگنال
موضوعات مرتبط
مهندسی و علوم پایه شیمی الکتروشیمی
چکیده انگلیسی


• A redox-capacitor film is fabricated electrochemically from chitosan and catechol.
• This redox-capacitor rapidly exchanges electrons with redox-cycling molecules.
• Cyclic potential inputs to the capacitor yield output signatures of redox-cycling.
• Potentially, this redox-capacitor offers unique capabilities for redox-biology.

Redox-cycling compounds can significantly impact biological systems and can be responsible for activities that range from pathogen virulence and contaminant toxicities, to therapeutic drug mechanisms. Current methods to identify redox-cycling activities rely on the generation of reactive oxygen species (ROS), and employ enzymatic or chemical methods to detect ROS. Here, we couple the speed and sensitivity of electrochemistry with the molecular-electronic properties of a bio-based redox-capacitor to generate signatures of redox-cycling. The redox capacitor film is electrochemically-fabricated at the electrode surface and is composed of a polysaccharide hydrogel with grafted catechol moieties. This capacitor film is redox-active but non-conducting and can engage diffusible compounds in either oxidative or reductive redox-cycling. Using standard electrochemical mediators ferrocene dimethanol (Fc) and Ru(NH3)6Cl3 (Ru3 +) as model redox-cyclers, we observed signal amplifications and rectifications that serve as signatures of redox-cycling. Three bio-relevant compounds were then probed for these signatures: (i) ascorbate, a redox-active compound that does not redox-cycle; (ii) pyocyanin, a virulence factor well-known for its reductive redox-cycling; and (iii) acetaminophen, an analgesic that oxidatively redox-cycles but also undergoes conjugation reactions. These studies demonstrate that the redox-capacitor can enlist the capabilities of electrochemistry to generate rapid and sensitive signatures of biologically-relevant chemical activities (i.e., redox-cycling).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioelectrochemistry - Volume 98, August 2014, Pages 94–102
نویسندگان
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