کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
12753 814 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stimulation of bone formation by zoledronic acid in particle-induced osteolysis
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Stimulation of bone formation by zoledronic acid in particle-induced osteolysis
چکیده انگلیسی

We investigated the effect of a single subcutaneous dose of zoledronic acid on particle-induced osteolysis and observed excessive regional new bone formation.We utilized the murine calvarial osteolysis model and polyethylene particles in C57BL/J6 mice. Twenty-eight mice were used, seven per group. Specimens were stained with Giemsa dye. The osteoid tissue area was determined. Bone thickness was measured as an indicator of bone growth.Net bone growth was significantly increased in animals with zoledronic acid treatment: 0.02 mm2±0.03 mm2 in animals with particle implantation only (group 2), 0.25 mm2±0.08 mm2 with particle implantation and zoledronic acid treatment directly after surgery (group 3; p=0.0018p=0.0018), and 0.21 mm2±0.11 mm2 with particle implantation and zoledronic acid treatment on the fourth postoperative day (group 4; p=0.0042p=0.0042). The mean bone thickness was 0.2 mm±0.04 mm (range 0.17 mm–0.31 mm) in group 1 (sham controls) and 0.16 mm±0.02 mm (range 0.14 mm–0.19 mm) in group 2, 0.31 mm±0.04 mm (range 0.28 mm–0.39 mm) in group 3, and 0.29 mm±0.02 mm (range 0.28 mm–0.34 mm) in group 4. Student's t  -test revealed a statistically significant difference between groups 2 and 3 (p=0.00042p=0.00042), and groups 2 and 4 (p=0.0019p=0.0019).In conclusion, our observational study suggests that zoledronic acid may stimulate bone apposition locally in the process of particle-induced osteolysis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 26, Issue 17, June 2005, Pages 3719–3725
نویسندگان
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