کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
12841 | 818 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Radiation synthesis of interpolymer polyelectrolyte complex and its application as a carrier for colon-specific drug delivery system
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Radiation synthesis of interpolymer polyelectrolyte complex and its application as a carrier for colon-specific drug delivery system Radiation synthesis of interpolymer polyelectrolyte complex and its application as a carrier for colon-specific drug delivery system](/preview/png/12841.png)
چکیده انگلیسی
Novel pH-sensitive interpolymer polyelectrolyte complex was synthesized by gamma radiation-induced copolymerization of acrylic acid (AAc) and dimethyl aminoethyl methacrylate (DMAEMA). pH-dependent swelling showed different phase transitions depending on the copolymer composition and also showed the interpolymer polyelectrolyte complex formation at pH values ranged from pH 3 to pH 4. FT-IR and TGA was employed to study the complex formation. The influence of copolymer composition and pH value of the surrounding medium on the type of water diffusion in the glassy polymer was discussed. The ability of the prepared copolymer to be used as drug carrier for colon-specific drug delivery system was estimated using ketoprofen as a model drug.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 26, Issue 15, May 2005, Pages 2733–2739
Journal: Biomaterials - Volume 26, Issue 15, May 2005, Pages 2733–2739
نویسندگان
Amr El-Hag Ali Said,