Stereoselective C-alkylation of an iron(II) dichloroclathrochelate via free-radical reactions with alcohols

► Iron(II) dichloroclathrochelate undergoes C-centered radical reactions with alcohols. ► C-centered radical alcohol derivatives yield C-alkylated macrobicycles. ► The reaction is first example of alkylation of a macrocyclic ligand with alcohols. ► Free-radical substitution with alcohols proceeds with high regioselectivity.