Synthesis, characterization and cytotoxicity of the Au(III) complexes with cyclic amine-based dithiocarbamate ligands

Seven new Au(III) complexes ([(PipDTC)AuCl2] (1), [(MoDTC)AuCl2] (2), [(BzoPizDTC)AuCl2] (3), [(TsPizDTC)AuCl2] (4), [(PizDTC)Au2Cl4] (5), [(MePizDTC)Au2Cl5] (6) and [(EtPizDTC)Au2Cl5] (7)) with cyclic amine-based dithiocarbamate have been synthesized, characterized and evaluated in vitro. The results indicate that these complexes exert selective cytotoxic effects against HL-60, BGC-823, Bel-7402 and KB cells lines. Complex 1 shows 11-, 5- and 1-folds higher cytotoxicity than cisplatin against KB, BGC-823 and Bel-7402 cell lines. Complex 2 exhibits higher cytotoxicity than cisplatin against BGC-823 and Bel-7402 cell lines. Complexes 3 and 4 display higher cytotoxicity than cisplatin against BGC-823 cell line. The nature of cyclic amine and the number of metal centers have important effects on cytotoxicity of these Au(III) complexes.

Seven new Au(III) complexes were synthesized, characterized and evaluated. Complex 1 exhibited 5-, 11- and 1-fold higher cytotoxicity than cisplatin against BGC-823, KB and Bel-7402 cell lines.Figure optionsDownload as PowerPoint slideHighlights
► Seven new Au(III) complexes were synthesized, characterized and evaluated.
► Most of the complexes exerted cytotoxicity against four cell lines with low IC50.
► Complex 1 exhibited 11-folds higher cytotoxicity than cisplatin against KB.
► The nature of cyclic-amine and number of metal centers affect on cytotoxicity.
► The corrected and annotated PDF are attached in the attachment.