Effects of protonation degree on photodynamic activity of zinc phthalocyanine substituted with 1,2-diethylamino

• Zinc phthalocyanines of differing protonation degree were prepared.
• Protonation degree can influence 1O2 generation ability of phthalocyanines.
• Protonation degree influences the photodynamic activity of phthalocyanines.

This work reports on the effects of protonation degree on the photodynamic activity of zinc phthalocyanine substituted with 1,2-diethylamino (ZnPc1). Photophysical properties, singlet oxygen generation ability and photodynamic anticancer activity of derivatives of ZnPc1 with different protonation degree were studied and compared. Results indicated that the protonation degree can greatly influence the photophysical and photochemical properties of ZnPc1, thereby affecting its photodynamic activity. When the mole ratio of ZnPc1 and hydrochloric acid (HCl) was 1:8, the derivative of ZnPc1 showed the best photodynamic activity.

Derivatives of ZnPc1 with different protonation degree were prepared. There is a close relationship between protonation degree and photodynamic activity. Protonation degree can influence the photophysical and photochemical properties of ZnPc1, thereby affecting its photodynamic activity.Figure optionsDownload as PowerPoint slide