کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1305884 | 975053 | 2011 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Rhenium(I) and technetium(I) complexes of a novel pyridyltriazole-based ligand containing an arylpiperazine pharmacophore: Synthesis, crystal structures, computational studies and radiochemistry Rhenium(I) and technetium(I) complexes of a novel pyridyltriazole-based ligand containing an arylpiperazine pharmacophore: Synthesis, crystal structures, computational studies and radiochemistry](/preview/png/1305884.png)
The preparation of two M(CO)3 complexes (M = Re and 99mTc) from a novel pyridyltriazole-based ligand 2 bearing the bioactive (2-methoxyphenyl)piperazine pharmacophore are described. Spectral data, X-ray structure and DFT calculations of the rhenium(I) complex as well as the 99mTc-labelling of 2 are reported. Both complexes were neutral and iso-structural. Moreover, the 99mTc-complex presented a suitable lipophilic character for its use as a CNS imaging agent.
Graphical AbstractThe preparation of two M(CO)3 complexes (M = Re and 99mTc) from a novel pyridyltriazole-based ligand 2 bearing the bioactive (2-methoxyphenyl)piperazine pharmacophore are described. Spectral data, X-ray structure and DFT calculations of the rhenium(I) complex as well as the 99mTc-labelling of 2 are reported. Both complexes were neutral and iso-structural. Moreover, the 99mTc-complex presented a suitable lipophilic character for its use as a CNS imaging agent.Figure optionsDownload as PowerPoint slideResearch Highlights
► A novel pyridyltriazole-based ligand bearing a bioactive moiety is reported.
► the corresponding Re- and Tc-complexes were neutral and iso-structural.
► 99mTc-complex presented a suitable lipophilicity for its use as a CNS imaging agent.
Journal: Inorganic Chemistry Communications - Volume 14, Issue 1, January 2011, Pages 238–242