SOD mimic activity, DNA binding and in-vitro antibacterial studies of drug based copper(II) complexes

Square pyramidal complexes [CuII(PFL)(bpa)Cl]∙5H2O (1) and [CuII(LFL)(bpa)Cl]∙5H2O (2) have been synthesized and characterized. Compounds were checked for their in-vitro antimicrobial activity against two Gram(+ ve) and three Gram(–ve) bacterial species. Intrinsic binding constant (Kb) of complexes with CT DNA were determined using absorption titration. Viscosity measurement suggests that complexes bind with CT DNA through partial nonclassical intercalative mode. Superoxide dismutase (SOD) like activity of the complexes was also compared with previously reported compounds.

Partial non-classical intercalators with diverse biological activity were prepared using fluoroquinolones. They showed better superoxide scavenging ability.Figure optionsDownload as PowerPoint slide